Gefitinib impurity 1 [675126-26-8]

MedChem Express

Gefitinib impurity 1 [675126-26-8]

10

675126-26-8

Research Use Only

99.59

C15H19N3O5

321.33

Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

N#CC1=CC(OCCCN2CCOCC2)=C(OC)C=C1[N+]([O-])=O

2°C to 8°C

12352200