GFRA1 / GFR Alpha Antibody (aa25-227)

LifeSpan BioSciences

GFRA1 / GFR Alpha Antibody (aa25-227)

23

Human GFRA1 / GFR Alpha

GDNF family receptor alpha-1, also known as the GDNF receptor, is a protein that in humans is encoded by the GFRA1 gene. It is mapped to chromosome 10q25.3. The protein encoded by this gene is a member of the GDNF receptor family. GFRA1 is released by neuronal cells, Schwann cells, and injured sciatic nerve. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is also a candidate gene for Hirschsprung disease. Soluble GFRA1 mediates robust recruitment of RET to lipid rafts via a mechanism requiring the RET tyrosine kinase.. IHC, IHC-P (0.5 - 1 µg/ml), WB (0.5 - 1 µg/ml) GDNF family receptor alpha-1, also known as the GDNF receptor, is a protein that in humans is encoded by the GFRA1 gene. It is mapped to chromosome 10q25.3. The protein encoded by this gene is a member of the GDNF receptor family. GFRA1 is released by neuronal cells, Schwann cells, and injured sciatic nerve. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is also a candidate gene for Hirschsprung disease. Soluble GFRA1 mediates robust recruitment of RET to lipid rafts via a mechanism requiring the RET tyrosine kinase.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

Unconjugated

Lyophilized

GFRA1

GDNF family receptor alpha 1

GDNF family receptor alpha-1; GDNF receptor alpha 1d; GDNF receptor alpha 1e; GDNFR; GDNFRA; GDNFR-alpha-1; GFR-ALPHA-1; GFRalpha-1; Glial cell line-derived neurotrophic factor receptor alpha; GPI-linked anchor protein; PI-linked cell-surface accessory protein; RET ligand 1; RET1L; RETL1; TGF-beta-related neurotrophic factor receptor 1; TRNR1

Rabbit

IgG

Human

-20°C,2°C to 8°C

12352203