GGTI298 [180977-44-0]

TargetMol Chemicals

GGTI298 [180977-44-0]

999

180977-44-0

Chemical

Research Use Only

GGTI298

C27H33N3O3S

479.63

GGTI298, a CAAZ peptidomimetic and potent geranylgeranyltransferase I (GGTase I) inhibitor, efficiently blocks the processing of geranylgeranylated Rap1A while exerting minimal impact on the processing of farnesylated Ha-Ras. The inhibitor displays in vivo IC50 values of 3 microM for Rap1A and >20 microM for Ha-Ras, respectively.

3 years

C(N[C@H](C(OC)=O)CC(C)C)(=O)C1=C(C=C(NC[C@H](CS)N)C=C1)C=2C3=C(C=CC2)C=CC=C3

-20°C

12352200