Gliotoxin

MedChem Express

Gliotoxin [67-99-2]

10

67-99-2

Research Use Only

99.51

C13H14N2O4S2

326.39

Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus , inhibits the phagocytosis of macrophages and the immune functions of other immune cells [1] . Gliotoxin inhibits inducible NF-kappaB activity by preventing IkappaB degradation, which consequently induces host-cell apoptosis [2] . Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells [3] . Gliotoxin is a potent NOTCH2 transactivation inhibitor, can effectively induce apoptosis of chronic lymphocytic leukemia (CLL) cells [4] .

O=C1N([C@]2(C(N3[C@]1(CC4=CC=C[C@@H]([C@@]34[H])O)SS2)=O)CO)C

-20°C

12352200