Gliotoxin [67-99-2]

TargetMol Chemicals

Gliotoxin [67-99-2]

9

67-99-2

Research Use Only

C13H14N2O4S2

326.39

Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. Gliotoxin is a mycotoxin produced by several moulds such as Aspergillus fumigatus. Gliotoxin activates PKA and increases intracellular cAMP concentration and inhibits inducible NF-kappaB activity by preventing IkappaB degradation, which consequently induces host-cell apoptosis.

CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3

-20°C

12352200