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Glucocorticoid Receptor antibody

GTX101120
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetNR3C1
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Overview

  • Supplier
    GeneTex
  • Product Name
    Glucocorticoid Receptor antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. IP: 1:500-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID2908
  • Target name
    NR3C1
  • Target description
    nuclear receptor subfamily 3 group C member 1
  • Target synonyms
    GCCR, GCR, GCRST, GR, GRL, glucocorticoid receptor, nuclear receptor subfamily 3 group C member 1 variant hGR-B(54), nuclear receptor subfamily 3 group C member 1 variant hGR-B(77), nuclear receptor subfamily 3 group C member 1 variant hGR-B(93), nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP04150
  • Protein Name
    Glucocorticoid receptor
  • Scientific Description
    The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Kunke M, Knöfler H, Dahlke E, et al. Targeted deletion of von-Hippel-Lindau in the proximal tubule conditions the kidney against early diabetic kidney disease. Cell Death Dis. 2023,14(8):562. doi: 10.1038/s41419-023-06074-7
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  • Butz H, Saskői É, Krokker L, et al. Context-Dependent Role of Glucocorticoid Receptor Alpha and Beta in Breast Cancer Cell Behaviour. Cells. 2023,12(5). doi: 10.3390/cells12050784
    Read this paper
  • Yang HH, Su SH, Ho CH, et al. Glucocorticoid Receptor Maintains Vasopressin Responses in Kidney Collecting Duct Cells. Front Physiol. 2022,13:816959. doi: 10.3389/fphys.2022.816959
    Read this paper
  • Ho CH, Yang HH, Su SH, et al. α-Actinin 4 Links Vasopressin Short-Term and Long-Term Regulation of Aquaporin-2 in Kidney Collecting Duct Cells. Front Physiol. 2021,12:725172. doi: 10.3389/fphys.2021.725172
    Read this paper
  • Yi S, Shi W, Zuo M, et al. Endoplasmic Reticulum Stress Is Involved in Glucocorticoid-Induced Apoptosis in PC12 Cells. Anal Cell Pathol (Amst). 2021,2021:5565671. doi: 10.1155/2021/5565671
    Read this paper
  • Sueyasu T, Morita S, Tokuda H, et al. Dietary arachidonic acid improves age-related excessive enhancement of the stress response. Eur Rev Med Pharmacol Sci. 2020,24(4):2110-2119. doi: 10.26355/eurrev_202002_20391
    Read this paper
  • Matsuzaki K, Sugimoto N, Islam R, et al. Salivary Immunoglobulin A Secretion and Polymeric Ig Receptor Expression in the Submandibular Glands Are Enhanced in Heat-Acclimated Rats. Int J Mol Sci. 2020,21(3). doi: 10.3390/ijms21030815
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  • Obradović MMS, Hamelin B, Manevski N, et al. Glucocorticoids promote breast cancer metastasis. Nature. 2019,567(7749):540-544. doi: 10.1038/s41586-019-1019-4
    Read this paper
  • Kim SR, Song JH, Ahn JH, et al. Antiviral and anti-inflammatory activity of budesonide against human rhinovirus infection mediated via autophagy activation. Antiviral Res. 2018,151:87-96. doi: 10.1016/j.antiviral.2018.01.012
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  • Wu YL, Chang JC, Lin WY, et al. Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway. Free Radic Biol Med. 2018,115:309-317. doi: 10.1016/j.freeradbiomed.2017.12.011
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