Glutathione Reductase antibody [N2C2], Internal
GTX114199
ApplicationsElectron Microscopy, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetGSR
Overview
- SupplierGeneTex
- Product NameGlutathione Reductase antibody [N2C2], Internal
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsElectron Microscopy, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.21 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID2936
- Target nameGSR
- Target descriptionglutathione-disulfide reductase
- Target synonymsepididymis luminal protein 75; epididymis secretory sperm binding protein Li 122m; glutathione reductase, mitochondrial; glutathione S-reductase; GR; GRase; GSRD; HEL-75; HEL-S-122m
- HostRabbit
- IsotypeIgG
- Protein IDP00390
- Protein NameGlutathione reductase, mitochondrial
- Scientific DescriptionThis gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Beneficial Effects of Glucagon-Like Peptide-1 (GLP-1) in Diabetes-Induced Retinal Abnormalities: Involvement of Oxidative Stress. Ramos H et al., 2020 Sep 10, Antioxidants (Basel)Read more
- The immunohistochemical and histologic effects of contrast medium on uterus, fallopian tubes and ovaries, given during hysterosalpingography: rat study. Pek E et al., 2020 Dec 4, J Turk Ger Gynecol AssocRead more
- Sesamin Enhances Nrf2-Mediated Protective Defense against Oxidative Stress and Inflammation in Colitis via AKT and ERK Activation. Bai X et al., 2019, Oxid Med Cell LongevRead more
- Choroid plexus glutathione peroxidases are instrumental in protecting the brain fluid environment from hydroperoxides during postnatal development. Saudrais E et al., 2018 Oct 1, Am J Physiol Cell PhysiolRead more
- Taurine treatment prevents derangement of the hepatic gamma-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism. Maclean KN et al., 2018 Mar, FASEB JRead more
- Angiotensin II type 1a receptor-deficient mice develop angiotensin II-induced oxidative stress and DNA damage without blood pressure increase. Zimnol A et al., 2017 Dec 1, Am J Physiol Renal PhysiolRead more
- Synthetic beta-nitrostyrene derivative CYT-Rx20 as inhibitor of oral cancer cell proliferation and tumor growth through glutathione suppression and reactive oxygen species induction. Wang YY et al., 2017 Jun, Head NeckRead more
- Shikonin inhibits oxidized LDL-induced monocyte adhesion by suppressing NFkappaB activation via up-regulation of PI3K/Akt/Nrf2-dependent antioxidation in EA.hy926 endothelial cells. Huang CS et al., 2015 Feb 1, Biochem PharmacolRead more
- Effect of glutathione reductase knockdown in response to UVB-induced oxidative stress in human lung adenocarcinoma. Chou HC et al., 2014 Jan 9, Proteome SciRead more
- Proteomic and redox-proteomic study on the role of glutathione reductase in human lung cancer cells. Fan CY et al., 2013 Dec, ElectrophoresisRead more