Bio-Connect

Glutathione Reductase antibody [N2C2], Internal

GTX114199
GeneTex
ApplicationsElectron Microscopy, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetGSR
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    Glutathione Reductase antibody [N2C2], Internal
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Electron Microscopy, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.21 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID2936
  • Target name
    GSR
  • Target description
    glutathione-disulfide reductase
  • Target synonyms
    CNSHA10, GR, GSRD, HEL-75, HEL-S-122m, glutathione reductase, mitochondrial, GRase, epididymis luminal protein 75, epididymis secretory sperm binding protein Li 122m, glutathione S-reductase
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP00390
  • Protein Name
    Glutathione reductase, mitochondrial
  • Scientific Description
    This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Lee KY, Yang CC, Shueng PW, et al. Downregulation of TAZ elicits a mitochondrial redox imbalance and ferroptosis in lung epithelial cells exposed to diesel exhaust particles. Ecotoxicol Environ Saf. 2023,266:115555. doi: 10.1016/j.ecoenv.2023.115555
    Read this paper
  • Ramos H, Bogdanov P, Sampedro J, et al. Beneficial Effects of Glucagon-Like Peptide-1 (GLP-1) in Diabetes-Induced Retinal Abnormalities: Involvement of Oxidative Stress. Antioxidants (Basel). 2020,9(9). doi: 10.3390/antiox9090846
    Read this paper
  • Pek E, Canbey Göret C, Hacıvelioğlu S, et al. The immunohistochemical and histologic effects of contrast medium on uterus, fallopian tubes and ovaries, given during hysterosalpingography: rat study. J Turk Ger Gynecol Assoc. 2020,21(4):243-254. doi: 10.4274/jtgga.galenos.2020.2019.0067
    Read this paper
  • Bai X, Gou X, Cai P, et al. Sesamin Enhances Nrf2-Mediated Protective Defense against Oxidative Stress and Inflammation in Colitis via AKT and ERK Activation. Oxid Med Cell Longev. 2019,2019:2432416. doi: 10.1155/2019/2432416
    Read this paper
  • Saudrais E, Strazielle N, Ghersi-Egea JF. Choroid plexus glutathione peroxidases are instrumental in protecting the brain fluid environment from hydroperoxides during postnatal development. Am J Physiol Cell Physiol. 2018,315(4):C445-C456. doi: 10.1152/ajpcell.00094.2018
    Read this paper
  • Maclean KN, Jiang H, Aivazidis S, et al. Taurine treatment prevents derangement of the hepatic γ-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism. FASEB J. 2018,32(3):1265-1280. doi: 10.1096/fj.201700586R
    Read this paper
  • Zimnol A, Amann K, Mandel P, et al. Angiotensin II type 1a receptor-deficient mice develop angiotensin II-induced oxidative stress and DNA damage without blood pressure increase. Am J Physiol Renal Physiol. 2017,313(6):F1264-F1273. doi: 10.1152/ajprenal.00183.2017
    Read this paper
  • Wang YY, Chen YK, Hsu YL, et al. Synthetic β-nitrostyrene derivative CYT-Rx20 as inhibitor of oral cancer cell proliferation and tumor growth through glutathione suppression and reactive oxygen species induction. Head Neck. 2017,39(6):1055-1064. doi: 10.1002/hed.24664
    Read this paper
  • Huang CS, Lin AH, Yang TC, et al. Shikonin inhibits oxidized LDL-induced monocyte adhesion by suppressing NFκB activation via up-regulation of PI3K/Akt/Nrf2-dependent antioxidation in EA.hy926 endothelial cells. Biochem Pharmacol. 2015,93(3):352-61. doi: 10.1016/j.bcp.2014.12.005
    Read this paper
  • Chou HC, Chan HL. Effect of glutathione reductase knockdown in response to UVB-induced oxidative stress in human lung adenocarcinoma. Proteome Sci. 2014,12(1):2. doi: 10.1186/1477-5956-12-2
    Read this paper