GMB-475

MedChem Express

GMB-475 [2490599-18-1]

9

2490599-18-1

Research Use Only

98.98

C43H46F3N7O7S

861.93

GMB-475 is a potent BCR-ABL1 PROTAC based on Von Hippel-Lindau (VHL) . GMB-475 targets the nutmeg pocket of ABL1 in an ectopic manner and degrades BCR-ABL1 protein through the ubiquitin proteasome pathway. GMB-475 inhibits the proliferation of human K562 cells and mouse Ba/F3 cells, and is used for the study of chronic myeloid leukemia. (Blue: VHL ligand (HY-125845); Black: Linker; Pink: BCR-ABL1 ligand (HY-11007)) [1] [2] .

FC(F)(F)OC1=CC=C(NC2=CC(C3=CC=C(OCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)C=C3)=NC=N2)C=C1

-20°C,2°C to 8°C

12352200