GMB-475 [2490599-18-1]

TargetMol Chemicals

GMB-475 [2490599-18-1]

9

2490599-18-1

Chemical

Research Use Only

GMB-475

C43H46F3N7O7S

861.93

GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein

3 years

Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOc2ccc(cc2)-c2cc(Nc3ccc(OC(F)(F)F)cc3)ncn2)C(C)(C)C)cc1

-20°C

12352200