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ProductsBack/GNE-1858 [2680616-96-8]
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GNE-1858 [2680616-96-8]

Research Use Only
T11438
TargetMol Chemicals
CAS Number2680616-96-8
DownloadMSDS
Product group Chemicals
Molecular Weight428.48
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    GNE-1858 [2680616-96-8]
  • Delivery Days Customer
    9
  • CAS Number
    2680616-96-8
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    GNE-1858
  • Molecular Formula
    C21H26F2N8
  • Molecular Weight
    428.48
  • Scientific Description
    GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA).
  • Shelf life instruction
    3 years
  • SMILES
    CC(C)n1ncc2cnc(Nc3cc(nc(n3)N3CCC(F)(F)C3)C3CCNC3)cc12
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Wu P, et al. Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer. Structure. 2019 Jan 2;27(1):125-133.e4.
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