GNE-207 [2158266-58-9]

MedChem Express

GNE-207 [2158266-58-9]

10

2158266-58-9

Research Use Only

99.94

C29H30N6O3

510.59

GNE-207 is a potent, selective and orally bioavailable inhibitor of the bromodomain of CBP, with an IC50 of 1 nM, exhibits a selectively index of >2500-fold against BRD4 (1). GNE-207 shows excellent CBP potency, with an EC50 of 18 nM for MYC expression in MV-4-11 cells[1].

O=C(NC)C1=NC=C(C2=CC3=C(C=N2)C(C4=NN(C5CCOCC5)C6=C4CN(C(C)=O)CC6)=CC=C3)C=C1

-20°C,2°C to 8°C

12352200