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GNE-490

HY-10812
MedChem Express
CAS Number1033739-92-2
DownloadMSDS
Product group Chemicals
Estimated Purity96.29
Molecular Weight386.47
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Overview

  • Supplier
    MedChem Express
  • Product Name
    GNE-490 [1033739-92-2]
  • Delivery Days Customer
    10
  • CAS Number
    1033739-92-2
  • Certification
    Research Use Only
  • Estimated Purity
    96.29
  • Molecular Formula
    C18H22N6O2S
  • Molecular Weight
    386.47
  • Scientific Description
    GNE-490, a (thienopyrimidin-2-yl)aminopyrimidine, is a potent pan- PI3K inhibitor with IC 50 s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kalpha, PI3Kbeta, PI3Kdelta and PI3Kgamma, respectively. GNE-490 has >200 fold selectivity for mTOR (IC 50 =750 nM). GNE-490 shows potent suppression efficacy profile against MCF7.1 breast cancer xenograft model [1] .
  • SMILES
    OC(C)(C)C1=CC(N=C(C2=CN=C(N)N=C2C)N=C3N4CCOCC4)=C3S1
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200