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GPR30 antibody [C2C3], C-term

GTX107748
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetGPER1
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Overview

  • Supplier
    GeneTex
  • Product Name
    GPR30 antibody [C2C3], C-term
  • Delivery Days Customer
    9
  • Antibody Specificity
    Knockdown/Knockout validation was supported by references (PMID:24039841)
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.53 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID2852
  • Target name
    GPER1
  • Target description
    G protein-coupled estrogen receptor 1
  • Target synonyms
    CEPR; chemoattractant receptor-like 2; chemokine receptor-like 2; CMKRL2; constitutively expressed peptide-like receptor; DRY12; FEG-1; flow-induced endothelial G-protein coupled receptor 1; G protein-coupled receptor 30; GPCR-Br; GPER; GPR30; G-protein coupled estrogen receptor 1; heptahelix receptor; IL8-related receptor DRY12; LERGU; LERGU2; LyGPR; lymphocyte-derived G-protein coupled receptor; membrane estrogen receptor; mER
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ99527
  • Protein Name
    G-protein coupled estrogen receptor 1
  • Scientific Description
    This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Activation of G protein coupled estrogen receptor prevents chemotherapy-induced intestinal mucositis by inhibiting the DNA damage in crypt cell in an extracellular signal-regulated kinase 1- and 2- dependent manner. Chen G et al., 2021 Oct 30, Cell Death Dis
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  • Activation of the G Protein-Coupled Estrogen Receptor Prevented the Development of Acute Colitis by Protecting the Crypt Cell. Wang Q et al., 2021 Feb, J Pharmacol Exp Ther
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  • Estrogen receptor signaling in the ferutinin-induced osteoblastic differentiation of human amniotic fluid stem cells. Zavatti M et al., 2016 Nov 1, Life Sci
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  • Estradiol rapidly modulates odor responses in mouse vomeronasal sensory neurons. Cherian S et al., 2014 Jun 6, Neuroscience
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  • Estradiol and tamoxifen induce cell migration through GPR30 and activation of focal adhesion kinase (FAK) in endometrial cancers with low or without nuclear estrogen receptor alpha (ERalpha). Tsai CL et al., 2013, PLoS One
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