GRID2 antibody

GeneTex

GRID2 antibody

9

WB: 1:500 - 1:1000. ICC/IF: 1:100 - 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Research Use Only

Polyclonal

Unconjugated

GRID2

glutamate ionotropic receptor delta type subunit 2

GluD2; gluR delta-2 subunit; glutamate receptor delta-2 subunit; glutamate receptor ionotropic, delta-2; glutamate receptor, ionotropic, delta 2; SCAR18

Rabbit

IgG

Glutamate receptor ionotropic, delta-2

The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named lurcher, in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014]

-20°C or -80°C,2°C to 8°C

12352203