Groenlandicine [38691-95-1]

MedChem Express

Groenlandicine [38691-95-1]

10

38691-95-1

Research Use Only

99.87

C19H16NO4+

322.34

Groenlandicine, a protoberberine alkaloid, is a cholinesterase inhibitor (AChE (IC50 = 0.54 microM), BChE (IC50 = 3.32 microM)). Groenlandicine non-competitively inhibits BACE1 (IC50 = 19.68 microM, Ki = 21.2) and inhibits RLAR (IC50 = 140.1 microM), HRAR (IC50 = 154.2 microM), and total ROS generation (IC50 = 51.78 microM) in vitro. Groenlandicine suppresses osteosarcoma cell proliferation while promoting apoptosis. Groenlandicine inhibits the tumor growth when combined with Cisplatin (HY-17394). Groenlandicine can be used for the study on osteosarcoma, Alzheimers disease and diabetes mellitus [1][2][3][4][5].

COC1=CC2=C(C=C1O)CC[N+]3=CC4=C(C=CC5=C4OCO5)C=C23

2°C to 8°C

12352200