GSK-114 [1301761-96-5]

MedChem Express

GSK-114 [1301761-96-5]

10

1301761-96-5

Research Use Only

99.52

C19H23N5O4S

417.48

GSK-114 is a highly selective, orally active TNNI3K inhibitor (IC50= 25 nM). GSK-114 shows a 40-fold selectivity for TNNI3K over B-Raf kinase (IC50= 1 microM). Cardiac troponin I-interacting kinase (TNNI3K or CARK) is a member of the tyrosine-like kinase family that is selectively expressed in heart tissue[1].

O=S(NC)(C1=CC=C(N(C)C)C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)=C1)=O

-20°C,2°C to 8°C

12352200