GSK-F1 [1402345-92-9]
SYN-1220
CAS Number1402345-92-9
Product group Chemicals
Estimated Purity>95%
Molecular Weight603.5
Overview
- SupplierSYNkinase
- Product NameGSK-F1 [1402345-92-9]
- Delivery Days Customer10
- CAS Number1402345-92-9
- CertificationResearch Use Only
- Estimated Purity>95%
- Hazard InformationWarning
- Molecular FormulaC27H18F5N5O4S
- Molecular Weight603.5
- Scientific DescriptionChemical. CAS: 1402345-92-9. Formula: C27H18F5N5O4S. MW: 603.5. GSK-F1 is a potent PI4KA inhibitor. It has better pharmacokinetic properties in vivo than to GSK-A1 (SYN-1219). GSK-F1 does not cross the blood-brain barrier. Phosphatidylinositol 4-kinase type IIIalpha (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for drug development. RNAi studies have shown that PI4KA is a mandatory host factor in HCV replication. Down-regulation of PI4KA appears to be reasonably tolerated by cultured cell models and results. - GSK-F1 is a potent PI4KA inhibitor. It has better pharmacokinetic properties in vivo than to GSK-A1 (SYN-1219). GSK-F1 does not cross the blood-brain barrier. Phosphatidylinositol 4-kinase type IIIalpha (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for drug development. RNAi studies have shown that PI4KA is a mandatory host factor in HCV replication. Down-regulation of PI4KA appears to be reasonably tolerated by cultured cell models and results.
- Storage Instruction2°C to 8°C
- UNSPSC51202000