GSK-J1 [1373422-53-7]
SYN-3030
CAS Number1373422-53-7
Product group Chemicals
Estimated Purity>95%
Molecular Weight389.5
Overview
- SupplierSYNkinase
- Product NameGSK-J1 [1373422-53-7]
- Delivery Days Customer10
- CAS Number1373422-53-7
- CertificationResearch Use Only
- Estimated Purity>95%
- Molecular FormulaC22H23N5O2
- Molecular Weight389.5
- Scientific DescriptionChemical. CAS: 1373422-53-7. Formula: C22H23N5O2. MW: 389.5. GSK-J1 is a potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A), with IC50 values of 28nM and 53nM, respectively. GSK-J1 also has less potent inhibitory activity against KDM5B, KDM5C and KDM5A, with IC50 values of 170, 550 and 6,800nM, respectively. It shows no activity against other histone demethylases (IC50 >20microM), and displays no significant inhibitory activity against 100 protein kinases at a concentration of 30microM. - GSK-J1 is a potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A), with IC50 values of 28nM and 53nM, respectively. GSK-J1 also has less potent inhibitory activity against KDM5B, KDM5C and KDM5A, with IC50 values of 170, 550 and 6,800nM, respectively. It shows no activity against other histone demethylases (IC50 >20microM), and displays no significant inhibitory activity against 100 protein kinases at a concentration of 30microM.
- Storage Instruction2°C to 8°C
- UNSPSC51202000