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GSK-J1 [1373422-53-7]

Research Use Only
SYN-3030
SYNkinase
CAS Number1373422-53-7
Product group Chemicals
Estimated Purity>95%
Molecular Weight389.5
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Overview

  • Supplier
    SYNkinase
  • Product Name
    GSK-J1 [1373422-53-7]
  • Delivery Days Customer
    10
  • CAS Number
    1373422-53-7
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C22H23N5O2
  • Molecular Weight
    389.5
  • Scientific Description
    Chemical. CAS: 1373422-53-7. Formula: C22H23N5O2. MW: 389.5. GSK-J1 is a potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A), with IC50 values of 28nM and 53nM, respectively. GSK-J1 also has less potent inhibitory activity against KDM5B, KDM5C and KDM5A, with IC50 values of 170, 550 and 6,800nM, respectively. It shows no activity against other histone demethylases (IC50 >20microM), and displays no significant inhibitory activity against 100 protein kinases at a concentration of 30microM. - GSK-J1 is a potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A), with IC50 values of 28nM and 53nM, respectively. GSK-J1 also has less potent inhibitory activity against KDM5B, KDM5C and KDM5A, with IC50 values of 170, 550 and 6,800nM, respectively. It shows no activity against other histone demethylases (IC50 >20microM), and displays no significant inhibitory activity against 100 protein kinases at a concentration of 30microM.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    51202000