GSK-J4 (hydrochloride)
HY-15648F
CAS Number1797983-09-5
Product group Chemicals
Estimated Purity99.01
Molecular Weight453.96
Overview
- SupplierMedChem Express
- Product NameGSK-J4 (hydrochloride) [1797983-09-5]
- Delivery Days Customer10
- CAS Number1797983-09-5
- CertificationResearch Use Only
- Estimated Purity99.01
- Molecular FormulaC24H28ClN5O2
- Molecular Weight453.96
- Scientific DescriptionGSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC 50 s of 8.6 and 6.6 microM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-alpha production in human primary macrophages with an IC 50 of 9 microM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1 [1] [2] [3] .
- SMILESO=C(OCC)CCNC1=NC(C2=CC=CC=N2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1.Cl
- Storage Instruction2°C to 8°C
- UNSPSC12352200
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