GSK-J4 (hydrochloride)

MedChem Express

GSK-J4 (hydrochloride) [1797983-09-5]

10

1797983-09-5

Research Use Only

99.01

C24H28ClN5O2

453.96

GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC 50 s of 8.6 and 6.6 microM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-alpha production in human primary macrophages with an IC 50 of 9 microM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1 [1] [2] [3] .

O=C(OCC)CCNC1=NC(C2=CC=CC=N2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1.Cl

2°C to 8°C

12352200