GSK-J4 hydrochloride
M2731
CAS Number1797983-09-5
Product group Chemicals
Estimated Purity0.9895
Molecular Weight453.96
Overview
- SupplierAbMole BioScience
- Product NameGSK-J4 hydrochloride
- Delivery Days Customer9
- CAS Number1797983-09-5
- Category SupplierChemical
- CertificationResearch Use Only
- Estimated Purity0.9895
- Molecular FormulaC24H27N5O2.HCl
- Molecular Weight453.96
- Scientific DescriptionGSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 uM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-alfa production in human primary macrophages with an IC50 of 9 uM. GSK J4 hydrochloride is a cell permeable procompound of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM and inactive against a panel of demethylases of the JMJ family.
- SMILESCl.CCOC(=O)CCNC1=CC(=NC(=N1)C2=CC=CC=N2)N3CCC4=C(CC3)C=CC=C4
- UNSPSC12352200
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