GSK2945 [1438071-12-5]
T11490
CAS Number1438071-12-5
Product group Chemicals
Molecular Weight421.34
Overview
- SupplierTargetMol Chemicals
- Product NameGSK2945 [1438071-12-5]
- Delivery Days Customer72
- CAS Number1438071-12-5
- CertificationResearch Use Only
- Chemical NameGSK2945
- Molecular FormulaC20H18Cl2N2O2S
- Molecular Weight421.34
- Scientific DescriptionGSK2945 is a highly specific Rev-erbalpha/REV-ERBalpha (mouse/human reverse erythroblastosis virus alpha) antagonist (EC50s: 21.5 microM and 20.8 microM). It enhances cholesterol 7alpha-hydroxylase (CYP7A1) level and cholesterol metabolism.
- Shelf life instruction3 years
- SMILESN(CC=1SC(N(=O)=O)=CC1)(CC2=C(C)C=C(Cl)C=C2)CC3=CC=C(Cl)C=C3
- Storage Instruction-20°C
- UNSPSC12352200
References
- Zhang T, Zhao M, Lu D, et al. REV-ERBα Regulates CYP7A1 Through Repression of Liver Receptor Homolog-1. Drug Metab Dispos. 2018,46(3):248-258. doi: 10.1124/dmd.117.078105Read this paper
MSDS
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