GW274150

MedChem Express

GW274150 [210354-22-6]

9

210354-22-6

Research Use Only

98.0

C8H17N3O2S

219.30

GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) ( IC 50 =2.19 microM; K d =40 nM) and rat iNOS ( ED 50 =1.15 microM). GW274150 also displays less potency for both humans or rats endothelial NOS ( eNOS ) and neuronal NOS ( nNOS ). GW274150 exerts a protective role in an acute model of lung injury inflammation [1] [2] .

N[C@@H](CCSCCNC(C)=N)C(O)=O

2°C to 8°C

12352200