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Immunohistochemistry of paraffin-embedded Human colon carcinoma tissue using HDAC1 Monoclonal Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Human colon carcinoma tissue using HDAC1 Monoclonal Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Human colon carcinoma tissue using HDAC1 Monoclonal Antibody at dilution of 1:200.

HDAC1 Monoclonal Antibody

Research Use Only
E-AB-22208
Elabscience
Product group Antibodies
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More than 130 suppliers
ISO certified
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Overview

  • Supplier
    Elabscience
  • Product Name
    HDAC1 Monoclonal Antibody
  • Delivery Days Customer
    12
  • Certification
    Research Use Only
  • Scientific Description
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates Lys-310 in RELA and thereby inhibits the transcriptional activity of NF-kappa-B.
  • UNSPSC
    12352203