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ProductsBack/HDAC3 antibody [C3], C-term

HDAC3 antibody [C3], C-term

GTX109679
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetHDAC3
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Overview

  • Supplier
    GeneTex
  • Product Name
    HDAC3 antibody [C3], C-term
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.66 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID8841
  • Target name
    HDAC3
  • Target description
    histone deacetylase 3
  • Target synonyms
    HD3, KDAC3, RPD3, RPD3-2, histone deacetylase 3, SMAP45, protein deacetylase HDAC3, protein deacylase HDAC3
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO15379
  • Protein Name
    Histone deacetylase 3
  • Scientific Description
    Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Xu Y, Xiong Y, Liu Y, et al. Activation of goblet cell Piezo1 alleviates mucus barrier damage in mice exposed to WAS by inhibiting H3K9me3 modification. Cell Biosci. 2023,13(1):7. doi: 10.1186/s13578-023-00952-5
    Read this paper
  • Richter HJ, Hauck AK, Batmanov K, et al. Balanced control of thermogenesis by nuclear receptor corepressors in brown adipose tissue. Proc Natl Acad Sci U S A. 2022,119(33):e2205276119. doi: 10.1073/pnas.2205276119
    Read this paper
  • Chen CY, Chen CC, Chuang WY, et al. Hydroxygenkwanin Inhibits Class I HDAC Expression and Synergistically Enhances the Antitumor Activity of Sorafenib in Liver Cancer Cells. Front Oncol. 2020,10:216. doi: 10.3389/fonc.2020.00216
    Read this paper
  • Huang D, Chen J, Yang L, et al. NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death. Nat Immunol. 2018,19(10):1112-1125. doi: 10.1038/s41590-018-0207-y
    Read this paper
  • Lee JY, Kuo CW, Tsai SL, et al. Inhibition of HDAC3- and HDAC6-Promoted Survivin Expression Plays an Important Role in SAHA-Induced Autophagy and Viability Reduction in Breast Cancer Cells. Front Pharmacol. 2016,7:81. doi: 10.3389/fphar.2016.00081
    Read this paper
  • Yuan H, Niu Y, Liu X, et al. Exercise increases the binding of MEF2A to the Cpt1b promoter in mouse skeletal muscle. Acta Physiol (Oxf). 2014,212(4):283-92. doi: 10.1111/apha.12395
    Read this paper
  • Chuang C, Pan J, Hawke DH, et al. NudC deacetylation regulates mitotic progression. PLoS One. 2013,8(9):e73841. doi: 10.1371/journal.pone.0073841
    Read this paper

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Figure 1. Western blot analysis of HDAC3 using anti-HDAC3 antibody (A00839). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 ug of sample under reducing conditions. Lane 1: human 293T whole cell lysates, Lane 2: human Hela whole cell lysates, Lane 3: human HepG2 whole cell lysates, Lane 4: human MOLT-4 whole cell lysates, Lane 5: human MCF-7 whole cell lysates, Lane 6: human K562 whole cell lysates, Lane 7: human CACO-2 whole cell lysates, Lane 8: rat thymus tissue lysates, Lane 9: rat C6 whole cell lysates, Lane 10: mouse ANA-1 whole cell lysates, Lane 11: mouse NIH/3T3 whole cell lysates. After electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA for 50-90 minutes. Blocked the membrane with 5% non-fat milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-HDAC3 antigen affinity purified polyclonal antibody (Catalog # A00839) at 0.5 microg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:5000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for HDAC3 at approximately 49 kDa. The expected band size for HDAC3 is at 49 kDa.
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