HDAC4 antibody [HDAC-144]
GTX12171
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetHDAC4
Overview
- SupplierGeneTex
- Product NameHDAC4 antibody [HDAC-144]
- Delivery Days Customer9
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDHDAC-144
- Concentration2 mg/ml
- ConjugateUnconjugated
- Gene ID9759
- Target nameHDAC4
- Target descriptionhistone deacetylase 4
- Target synonymsAHO3; BDMR; HA6116; HD4; HDAC-4; HDACA; HDAC-A; histone deacetylase 4; histone deacetylase A
- HostMouse
- IsotypeIgG2a
- Scientific DescriptionChromatin is a highly specialized structure composed of tightly compacted chromosomal DNA. Gene expression within the nucleus is controlled, in part, by a host of protein complexes which continuously pack and unpack the chromosomal DNA. One of the known mechanisms of this packing and unpacking process involves the acetylation and deacetylation of the histone proteins comprising the nucleosomal core. Acetylated histone proteins confer accessibility of the DNA template to the transcriptional machinery for expression. Histone deacetylases (HDACs) are chromatin remodeling factors that deacetylate histone proteins and thus, may act as transcriptional repressors. HDACs are classified by their sequence homology to the yeast HDACs and there are currently 2 classes. Class I proteins are related to Rpd3 and members of class II resemble Hda1p.
- ReactivityHuman, Mouse, Rat
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203
References
- MicroRNA-1 and -499 regulate differentiation and proliferation in human-derived cardiomyocyte progenitor cells. Sluijter JP et al., 2010 Apr, Arterioscler Thromb Vasc BiolRead more