Chemical Structure
Heliquinomycin [178182-49-5]
AG-CN2-0091
Overview
- SupplierAdipoGen Life Sciences
- Product NameHeliquinomycin
- Delivery Days Customer10
- CAS Number178182-49-5
- CertificationResearch Use Only
- Estimated Purity>80%
- Hazard InformationWarning
- Molecular FormulaC33H30O17
- Molecular Weight698.6
- Scientific DescriptionAntibiotic [1]. DNA helicase inhibitor [1]. Inhibits the DNA helicase activity of the human minichromosome maintenance (MCM) 4/6/7 complex [3, 4]. Topoisomerase I and II inhibitor (weaker than DNA helicase) [2]. DNA and RNA synthesis inhibitor in cell culture. Does not inhibit protein synthesis [2]. Induces cell cycle arrest [2]. Anticancer compound [1, 2]. Antibacterial against Gram-positive bacteria [1]. - Chemical. CAS: 178182-49-5. Formula: C33H30O17. MW: 698.6. Isolated from Streptomyces sp. MJ929-SF2. Antibiotic. DNA helicase inhibitor. Inhibits the DNA helicase activity of the human minichromosome maintenance (MCM) 4/6/7 complex. Topoisomerase I and II inhibitor (weaker than DNA helicase). DNA and RNA synthesis inhibitor in cell culture. Does not inhibit protein synthesis. Induces cell cycle arrest. Anticancer compound. Antibacterial against Gram-positive bacteria.
- SMILESCOC1CC(O[C@@H]2C3=C(O[C@@]22OC4=C(C[C@H]2O)C=C2C=C(OC(=O)C2=C4O)C(=O)OC)C(O)=C2C(=O)C(OC)=CC(=O)C2=C3O)OC(C)C1O
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200
References
- Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physico-chemical properties and biological activities: M. Chino, et al.; J. Antibiot. 49, 752 (1996)
- Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth: M. Chino, et al.; J. Antibiot. 51, 480 (1998)
- Effect of heliquinomycin on the activity of human minichromosome maintenance 4/6/7 helicase: Y. Ishimi, et al.; FEBS J. 276, 3382 (2009)
- Interaction of heliquinomycin with single-stranded DNA inhibits MCM4/6/7 helicase: T. Sugiyama, et al.; J. Biochem. 151, 129 (2012)