HIF2 alpha antibody [GT125]
GTX632015
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetEPAS1
Overview
- SupplierGeneTex
- Product NameHIF2 alpha antibody [GT125]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IP: 1:100-1:700. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDGT125
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID2034
- Target nameEPAS1
- Target descriptionendothelial PAS domain protein 1
- Target synonymsECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73, endothelial PAS domain-containing protein 1, EPAS-1, HIF-1-alpha-like factor, HIF-1alpha-like factor, HIF-2-alpha, HIF2-alpha, PAS domain-containing protein 2, basic-helix-loop-helix-PAS protein MOP2, class E basic helix-loop-helix protein 73, hypoxia-inducible factor 2 alpha, member of PAS protein 2
- HostMouse
- IsotypeIgG1
- Protein IDQ99814
- Protein NameEndothelial PAS domain-containing protein 1
- Scientific DescriptionThis gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Kundu A, Nam H, Shelar S, et al. PRDM16 suppresses HIF-targeted gene expression in kidney cancer. J Exp Med. 2020,217(6). doi: 10.1084/jem.20191005Read this paper
- Chen L, Xia G, Qiu F, et al. Physapubescin selectively induces apoptosis in VHL-null renal cell carcinoma cells through down-regulation of HIF-2α and inhibits tumor growth. Sci Rep. 2016,6:32582. doi: 10.1038/srep32582Read this paper
- Lin CS, Lee HT, Lee MH, et al. Role of Mitochondrial DNA Copy Number Alteration in Human Renal Cell Carcinoma. Int J Mol Sci. 2016,17(6). doi: 10.3390/ijms17060814Read this paper

![WB analysis of hypoxia-treated A549 cell lysate using GTX30123 HIF2 alpha antibody [ep190b]. Lane 1: normoxic A549 lysate control Lane 2: hypoxic A549 lysate](https://www.genetex.com/upload/website/prouct_img/normal/GTX30123/GTX30123_1335_WB_w_23060722_677.webp)
