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HIF2 alpha antibody [GT125]

GTX632015
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetEPAS1
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Overview

  • Supplier
    GeneTex
  • Product Name
    HIF2 alpha antibody [GT125]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IP: 1:100-1:700. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    GT125
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID2034
  • Target name
    EPAS1
  • Target description
    endothelial PAS domain protein 1
  • Target synonyms
    ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73, endothelial PAS domain-containing protein 1, EPAS-1, HIF-1-alpha-like factor, HIF-1alpha-like factor, HIF-2-alpha, HIF2-alpha, PAS domain-containing protein 2, basic-helix-loop-helix-PAS protein MOP2, class E basic helix-loop-helix protein 73, hypoxia-inducible factor 2 alpha, member of PAS protein 2
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDQ99814
  • Protein Name
    Endothelial PAS domain-containing protein 1
  • Scientific Description
    This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Kundu A, Nam H, Shelar S, et al. PRDM16 suppresses HIF-targeted gene expression in kidney cancer. J Exp Med. 2020,217(6). doi: 10.1084/jem.20191005
    Read this paper
  • Chen L, Xia G, Qiu F, et al. Physapubescin selectively induces apoptosis in VHL-null renal cell carcinoma cells through down-regulation of HIF-2α and inhibits tumor growth. Sci Rep. 2016,6:32582. doi: 10.1038/srep32582
    Read this paper
  • Lin CS, Lee HT, Lee MH, et al. Role of Mitochondrial DNA Copy Number Alteration in Human Renal Cell Carcinoma. Int J Mol Sci. 2016,17(6). doi: 10.3390/ijms17060814
    Read this paper