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ProductsBack/Homocarbonyltopsentin [172286-77-0]
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Homocarbonyltopsentin [172286-77-0]

Research Use Only
T13723
TargetMol Chemicals
CAS Number172286-77-0
DownloadMSDS
Product group Chemicals
Molecular Weight370.36
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Homocarbonyltopsentin [172286-77-0]
  • Delivery Days Customer
    72
  • CAS Number
    172286-77-0
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    Homocarbonyltopsentin
  • Molecular Formula
    C21H14N4O3
  • Molecular Weight
    370.36
  • Scientific Description
    Homocarbonyltopsentin is a small-molecule TSL2-binding compound, binds to pentaloop conformations of TSL2 and promotes a shift to triloop conformations that display enhanced SMN2 exon 7 (E7) splicing (EC50: 16 microM).
  • Shelf life instruction
    3 years
  • SMILES
    Oc1ccc2c(c[nH]c2c1)C(=O)c1ncc([nH]1)C(=O)c1c[nH]c2ccccc12
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Garcia-Lopez A, et al. Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes. Nat Commun. 2018 May 23;9(1):2032.
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