HPK1-IN-7

MedChem Express

HPK1-IN-7 [2320462-65-3]

10

2320462-65-3

Research Use Only

99.33

C24H22N6O4

458.47

HPK1-IN-7 is a potent, orally active HPK1 (hematopoietic progenitor kinase 1, MAP4K1) inhibitor (IC50=2.6 nM) with excellent family and kinome selectivity. HPK1-IN-7 shows selectivity against IRAK4 (59 nM) and GLK (140 nM). HPK1-IN-7 shows robust efficacy against MC38 syngeneic tumor model in combination with anti-PD1[1].

O=C1OC(C)(C)C2=C1C=CC(NC3=NC=C(C4=NN=CO4)C(N[C@@H](C5=CC=CC=C5)CO)=N3)=C2

-20°C,2°C to 8°C

12352200