hSMG-1 inhibitor 11j

MedChem Express

hSMG-1 inhibitor 11j [1402452-15-6]

10

1402452-15-6

Research Use Only

99.82

C27H28ClN7O3S

566.07

hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kalpha/gamma (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 microM). hSMG-1 inhibitor 11j can be used for the research of cancer[1].

O=S(C1=CC(NC2=NC=CC(C3=CC(C4=CC=C(NC(NC)=O)C=C4)=NC=C3)=N2)=CC=C1Cl)(N(CC)CC)=O

2°C to 8°C

12352200