Human CD137L / TNFSF9 recombinant protein (Active) (His-tagged, C-ter)

Arigo Biolaboratories

Human CD137L / TNFSF9 recombinant protein (Active) (His-tagged, C-ter)

23

Other Application

Research Use Only

>95%

TNFSF9

TNF superfamily member 9

4-1BB-L, CD137L, TNLG5A, tumor necrosis factor ligand superfamily member 9, 4-1BB ligand, 4-1BBL, CD137 ligand, homolog of mouse 4-1BB-L, receptor 4-1BB ligand, tumor necrosis factor (ligand) superfamily, member 9, tumor necrosis factor ligand 5A, tumor necrosis factor superfamily member 9

Tumor necrosis factor ligand superfamily member 9

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]

-20°C

41116120

Human