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IHC-P analysis of human tonsil tissue using GTX01856 Human IgM antibody [8H6]. Note intense staining of plasma cells, weaker staining of follicular dendritic cell network and some B cells.
IHC-P analysis of human tonsil tissue using GTX01856 Human IgM antibody [8H6]. Note intense staining of plasma cells, weaker staining of follicular dendritic cell network and some B cells.
IHC-P analysis of human tonsil tissue using GTX01856 Human IgM antibody [8H6]. Note intense staining of plasma cells, weaker staining of follicular dendritic cell network and some B cells.

Human IgM antibody [8H6]

Research Use Only
GTX01856
GeneTex
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetIGHM
Price on request
Packing Size
Large volume orders?
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Overview

  • Supplier
    GeneTex
  • Product Name
    Human IgM antibody [8H6]
  • Delivery Days Customer
    9
  • Applications
    ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    8H6
  • Conjugate
    Unconjugated
  • Gene ID3507
  • Target name
    IGHM
  • Target description
    immunoglobulin heavy constant mu
  • Target synonyms
    AGM1; constant region of heavy chain of IgM; immunoglobulin mu chain; MU; VH
  • Host
    Mouse
  • Isotype
    IgG2a
  • Scientific Description
    Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).[supplied by OMIM, Aug 2010]
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203