IACS-010759 (hydrochloride)

MedChem Express

IACS-010759 (hydrochloride) [1807523-99-4]

10

1807523-99-4

Research Use Only

99.82

C25H26ClF3N6O4S

599.02

IACS-010759 hydrochlorideis an orally active, potent mitochondrial complex I of oxidative phosphorylation (OXPHOS) inhibitor. IACS-010759 hydrochlorideinhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS. IACS-010759 hydrochloride has the potential for relapsed/refractory AML and solid tumors research [1] [2] .

FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC(N5CCC(S(=O)(C)=O)CC5)=CC=C4)C(C)=N3)=N2)C=C1.Cl

2°C to 8°C

12352200