IACS-13909

MedChem Express

IACS-13909 [2160546-07-4]

10

2160546-07-4

99.97

C17H18Cl2N6

377.27

IACS-13909 is a selective, potent and orally active SHP2 allosteric inhibitor with an IC 50 of 15.7 nM and a K d of 32 nM. IACS-13909 is more selective for SHP2 than other phosphatases (including SHP1). IACS-13909 has antitumor activities and suppresses MAPK pathway signaling in receptor tyrosine kinases (RTK)-dependent cancers [1] .

NC1(C)CCN(C2=CN=C3C(NN=C3C4=CC=CC(Cl)=C4Cl)=N2)CC1

-20°C,2°C to 8°C

12352200