IACS-13909

AbMole BioScience

IACS-13909

9

2160546-07-4

Chemical

Research Use Only

C17H18Cl2N6

377.27

IACS-13909 is a potent selective, orally active SHP2 allosteric inhibitor IC50 for 15.7 nM,Kd 32 nM. IACS-13909 is more selective for SHP2 than other phosphatase, including SHP1. IACS-13909 inhibits the signaling of the receptor tyrosine kinase (RTK)/MAPK pathway and has an anticancer effect.

CC1(N)CCN(CC1)C2=CN=C3C(=N2)[NH]N=C3C4=CC=CC(=C4Cl)Cl

12352200