IDH2 (N) Antibody, Rabbit Polyclonal

Biorbyt

IDH2 antibody

16

WB:1:1000-1:5000 WB

IDH2

isocitrate dehydrogenase (NADP(+)) 2

D2HGA2; ICD-M; IDH; IDHM; IDP; IDPM; isocitrate dehydrogenase (NADP(+)) 2, mitochondrial; isocitrate dehydrogenase [NADP], mitochondrial; isocitrate dehydrogenase 2 (NADP+), mitochondrial; mNADP-IDH; NADP(+)-specific ICDH; oxalosuccinate decarboxylase

Isocitrate dehydrogenase [NADP], mitochondrial

Rabbit polyclonal to IDH2.Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate.These enzymes belong to two distinct subclasses, one utilizes NAD(+) as the electron acceptor andthe other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependentwhich localize to the mitochondrial matrix; and two NADP(+)-dependent, one of which is mitochondrialand the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. IDH2 isthe NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria, which plays a role inintermediary metabolism and energy production. IDH2 may tightly associate or interact with thepyruvate dehydrogenase complex. Defects in IDH2 are the cause of D-2-hydroxyglutaric aciduria type2 (D2HGA2), a neurometabolic disorder causing developmental delay, epilepsy, hypotonia, anddysmorphic features.

-20°C

12352203