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IDH3A antibody

GTX114486
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetIDH3A
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Overview

  • Supplier
    GeneTex
  • Product Name
    IDH3A antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:1000-1:10000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.63 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3419
  • Target name
    IDH3A
  • Target description
    isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
  • Target synonyms
    RP90, isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, H-IDH alpha, NAD(+)-specific ICDH subunit alpha, NAD(H)-specific isocitrate dehydrogenase alpha subunit, NAD+-specific ICDH, isocitrate dehydrogenase (NAD(+)) 3 alpha, isocitrate dehydrogenase (NAD+) alpha chain, isocitrate dehydrogenase 3 (NAD(+)) alpha, isocitrate dehydrogenase 3 (NAD+) alpha, isocitric dehydrogenase subunit alpha
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP50213
  • Protein Name
    Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
  • Scientific Description
    Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Lin ZH, Chang SY, Shen WC, et al. Isocitrate Dehydrogenase Alpha-1 Modulates Lifespan and Oxidative Stress Tolerance in Caenorhabditis elegans. Int J Mol Sci. 2022,24(1). doi: 10.3390/ijms24010612
    Read this paper
  • Yang C, Fan J, Zhuang Z, et al. The role of NAD(+)-dependent isocitrate dehydrogenase 3 subunit α in AFB1 induced liver lesion. Toxicol Lett. 2014,224(3):371-9. doi: 10.1016/j.toxlet.2013.10.037
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  • MacDonald MJ, Brown LJ, Longacre MJ, et al. Knockdown of both mitochondrial isocitrate dehydrogenase enzymes in pancreatic beta cells inhibits insulin secretion. Biochim Biophys Acta. 2013,1830(11):5104-11. doi: 10.1016/j.bbagen.2013.07.013
    Read this paper