IDH3A antibody
GTX114486
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetIDH3A
Overview
- SupplierGeneTex
- Product NameIDH3A antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:1000-1:10000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.63 mg/ml
- ConjugateUnconjugated
- Gene ID3419
- Target nameIDH3A
- Target descriptionisocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
- Target synonymsRP90, isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, H-IDH alpha, NAD(+)-specific ICDH subunit alpha, NAD(H)-specific isocitrate dehydrogenase alpha subunit, NAD+-specific ICDH, isocitrate dehydrogenase (NAD(+)) 3 alpha, isocitrate dehydrogenase (NAD+) alpha chain, isocitrate dehydrogenase 3 (NAD(+)) alpha, isocitrate dehydrogenase 3 (NAD+) alpha, isocitric dehydrogenase subunit alpha
- HostRabbit
- IsotypeIgG
- Protein IDP50213
- Protein NameIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
- Scientific DescriptionIsocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Lin ZH, Chang SY, Shen WC, et al. Isocitrate Dehydrogenase Alpha-1 Modulates Lifespan and Oxidative Stress Tolerance in Caenorhabditis elegans. Int J Mol Sci. 2022,24(1). doi: 10.3390/ijms24010612Read this paper
- Yang C, Fan J, Zhuang Z, et al. The role of NAD(+)-dependent isocitrate dehydrogenase 3 subunit α in AFB1 induced liver lesion. Toxicol Lett. 2014,224(3):371-9. doi: 10.1016/j.toxlet.2013.10.037Read this paper
- MacDonald MJ, Brown LJ, Longacre MJ, et al. Knockdown of both mitochondrial isocitrate dehydrogenase enzymes in pancreatic beta cells inhibits insulin secretion. Biochim Biophys Acta. 2013,1830(11):5104-11. doi: 10.1016/j.bbagen.2013.07.013Read this paper




![ICC/IF analysis of COS7 cells transiently transfected with IDH3A plasmid using GTX84317 IDH3A antibody [2F11].](https://www.genetex.com/upload/website/prouct_img/normal/GTX84317/GTX84317_1026_ICCIF_w_23061420_582.webp)
![ICC/IF analysis of COS7 cells transiently transfected with IDH3A plasmid using GTX84318 IDH3A antibody [5D2].](https://www.genetex.com/upload/website/prouct_img/normal/GTX84318/GTX84318_1028_ICCIF_w_23061420_606.webp)
