WB analysis of samples using GTX25681 IGF1R beta (phospho Tyr1131 / Tyr1135 / Tyr1136) / Insulin Receptor beta (phospho Tyr1146 / Tyr1150 / Tyr1151) antibody. The data show that only the immunogen phosphopeptide blocks the signal, demonstrating the specificity of the antibody.
WB analysis of samples using GTX25681 IGF1R beta (phospho Tyr1131 / Tyr1135 / Tyr1136) / Insulin Receptor beta (phospho Tyr1146 / Tyr1150 / Tyr1151) antibody. The data show that only the immunogen phosphopeptide blocks the signal, demonstrating the specificity of the antibody.
IGF1R beta (phospho Tyr1131 / Tyr1135 / Tyr1136) / Insulin Receptor beta (phospho Tyr1146 / Tyr1150 / Tyr1151) antibody
GTX25681
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
TargetINSR
Overview
- SupplierGeneTex
- Product NameIGF1R (phospho Tyr1131 / Tyr1135 / Tyr1136) / Insulin Receptor (phospho Tyr1146 / Tyr1150 / Tyr1151) antibody - Orthogonal Validated
- Delivery Days Customer9
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID3643
- Target nameINSR
- Target descriptioninsulin receptor
- Target synonymsCD220; HHF5; insulin receptor; IR
- HostRabbit
- IsotypeIgG
- Protein IDP06213
- Protein NameInsulin receptor
- Scientific DescriptionThis gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome. Zuliani I et al., 2021 Jan, NeurotherapeuticsRead more
- Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome. Tramutola A et al., 2020 Apr, Neurobiol DisRead more
- Inhibition of DNA methyltransferase 1 increases nuclear receptor subfamily 4 group A member 1 expression and decreases blood glucose in type 2 diabetes. Chen YT et al., 2016 Jun 28, OncotargetRead more
- Altered intracellular calcium fluxes in pancreatic cancer induced diabetes mellitus: Relevance of the S100A8 N-terminal peptide (NT-S100A8). Basso D et al., 2011 Feb, J Cell PhysiolRead more
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