ProductsBack/IGF1R beta (phospho Tyr1131 / Tyr1135 / Tyr1136) / Insulin Receptor beta (phospho Tyr1146 / Tyr1150 / Tyr1151) antibody

IGF1R beta (phospho Tyr1131 / Tyr1135 / Tyr1136) / Insulin Receptor beta (phospho Tyr1146 / Tyr1150 / Tyr1151) antibody

Name: IGF1R beta (phospho Tyr1131 / Tyr1135 / Tyr1136) / Insulin Receptor beta (phospho Tyr1146 / Tyr1150 / Tyr1151) antibody
SKU: GTX25681_G10
Availability: BackOrder

GTX25681

ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Product group Antibodies

ReactivityChicken, Human, Mouse, Rat

TargetINSR

Overview

Supplier
GeneTex
Product Name
IGF1R beta (phospho Tyr1131 / Tyr1135 / Tyr1136) / Insulin Receptor beta (phospho Tyr1146 / Tyr1150 / Tyr1151) antibody
Delivery Days Customer
9
Applications
Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID3643
Target name
INSR
Target description
insulin receptor
Target synonyms
CD220, HHF5, insulin receptor, IR
Host
Rabbit
Isotype
IgG
Protein IDP06213
Protein Name
Insulin receptor
Scientific Description
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Reactivity
Chicken, Human, Mouse, Rat
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Zuliani I, Lanzillotta C, Tramutola A, et al. The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome. Neurotherapeutics. 2021,18(1):340-363. doi: 10.1007/s13311-020-00978-4
Read this paper
Tramutola A, Lanzillotta C, Di Domenico F, et al. Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome. Neurobiol Dis. 2020,137:104772. doi: 10.1016/j.nbd.2020.104772
Read this paper
Chen YT, Liao JW, Tsai YC, et al. Inhibition of DNA methyltransferase 1 increases nuclear receptor subfamily 4 group A member 1 expression and decreases blood glucose in type 2 diabetes. Oncotarget. 2016,7(26):39162-39170. doi: 10.18632/oncotarget.10043
Read this paper
Basso D, Greco E, Padoan A, et al. Altered intracellular calcium fluxes in pancreatic cancer induced diabetes mellitus: Relevance of the S100A8 N-terminal peptide (NT-S100A8). J Cell Physiol. 2011,226(2):456-68. doi: 10.1002/jcp.22355
Read this paper