IKB beta antibody

GeneTex

IKB beta antibody

9

ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, ImmunoCytoChemistry

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

NFKBIB

NFKB inhibitor beta

IKBB, TRIP9, NF-kappa-B inhibitor beta, I-kappa-B-beta, NF-kappa-BIB, TR-interacting protein 9, TRIP-9, ikB-B, ikB-beta, ikappaBbeta, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta, thyroid receptor-interacting protein 9

Rabbit

IgG

NF-kappa-B inhibitor beta

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]

-20°C or -80°C,2°C to 8°C

12352203