IL-1alpha (mouse) Matched Pair Detection Set
AG-46B-0004
Overview
- SupplierAdipoGen Life Sciences
- Product NameIL-1alpha (mouse) Matched Pair Detection Set
- Delivery Days Customer10
- ApplicationsELISA
- Assay Detection Range15.6 to 2000pg/ml
- Assay Sensitivity10pg/ml
- Assay SpecificityDetects mouse IL-1alpha. Does not detect human IL-1alpha or mouse IL-1beta.
- CertificationResearch Use Only
- Scientific DescriptionMatched Pair Detection Set. Detects mouse IL-1alpha. Does not detect human IL-1alpha or mouse IL-1beta. Colorimetric assay. Sample Type: Cell Culture Supernatant. Range: 15.6 to 2000pg/ml. Sensitivity: 10pg/ml. The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner. - The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
- ReactivityMouse
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC41116133