Bio-Connect

IL-36alpha (aa 6-158) (human) (rec.) (untagged)

AG-40B-0165
AdipoGen Life Sciences
Protein IDQ9UHA7
Product group Proteins / Signaling Molecules
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    IL-36alpha (aa 6-158) (human) (rec.) (untagged)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Concentration
    0.1 mg/ml
  • Estimated Purity
    >95%
  • Protein IDQ9UHA7
  • Protein Name
    Interleukin-36 alpha
  • Scientific Description
    IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines has been shown to occur at different sites including the lung and skin and can be derived from diverse cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. Recently a novel role for IL-36alpha in the pathogenesis of intestinal inflammation has been reported. - Protein. Human IL-36alpha (aa Lys6-Phe158) is untagged. Source: E. coli. Endotoxin content: 95% (SDS-PAGE). IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines has been shown to occur at different sites including the lung and skin and can be derived from diverse cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. Recently a novel role for IL-36alpha in the pathogenesis of intestinal inflammation has been reported.
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352202

Related products

Product group Proteins / Signaling Molecules
MedChem Express
Protein IDQ9UHA7
  • SizePrice
Product group Proteins / Signaling Molecules
Sino Biological
Protein IDQ9UHA7
  • SizePrice
Product group Proteins / Signaling Molecules
RayBiotech
Protein IDQ9UHA7
  • SizePrice
Product group Proteins / Signaling Molecules
AdipoGen Life Sciences
Protein IDQ9JLA2
  • SizePrice
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Product group Proteins / Signaling Molecules
Cusabio
Protein IDQ9UHA7
  • SizePrice
Product group Proteins / Signaling Molecules
GeneTex
ApplicationsNeutralisation/Blocking
  • SizePrice
IL-36 alpha/IL-1F6 Protein, Human, Recombinant (aa 6-158)
Product group Proteins / Signaling Molecules
TargetMol Chemicals
  • SizePrice
SDS- PAGE analysis of recombinant human IL-36 alpha
Product group Proteins / Signaling Molecules
Boster Bio
ApplicationsOther Application
Protein IDQ9UHA7
  • SizePrice
Product group Proteins / Signaling Molecules
Cloud-Clone Corp.
Protein IDQ9UHA7
  • SizePrice
Product group Proteins / Signaling Molecules
Biomatik
Protein IDQ9UHA7
  • SizePrice