IL-38 (aa 3-152) (mouse) (rec.) (FLAG)
AG-40B-0101
Overview
- SupplierAdipoGen Life Sciences
- Product NameIL-38 (aa 3-152) (mouse) (rec.) (FLAG)
- Delivery Days Customer10
- CertificationResearch Use Only
- Concentration0.1 mg/ml
- Estimated Purity>95%
- Protein IDQ8R459
- Protein NameInterleukin-1 family member 10
- Scientific DescriptionIL-38 (IL-1F10) mRNA is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36alpha, IL-36beta or IL-36gamma) is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1; TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation. - Recombinant Protein. Mouse IL-38 [IL-1F10] (aa 3-152) is fused at the C-terminus to a FLAG®-tag. Source: E. coli. Lyophilized. Contains PBS + 0.5% Trehalose + 0.02% CHAPS. IL-38 (IL-1F10) mRNA is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36alpha, IL-36beta or IL-36gamma) is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1; TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation.
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352202