IL1 alpha Antibody / IL1A

Biorbyt

IL1 alpha Antibody / IL1A

10

Optimal dilution of the IL1A antibody should be determined by the researcher.

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT IHC-P

Research Use Only

Monoclonal

IL1A/3981

Unconjugated

IL1A

interleukin 1 alpha

IL-1 alpha, IL-1A, IL1, IL1-ALPHA, IL1F1, interleukin-1 alpha, hematopoietin-1, preinterleukin 1 alpha, pro-interleukin-1-alpha

Mouse

IgG2b

Interleukin-1 alpha

Two forms of interleukin-1, designated IL-1 alpha and beta, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1a and IL-1b bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1 for production of the anti-pathogen IFN-. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.

Human

-20°C,2°C to 8°C

12352203