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ProductsBack/IL1 beta antibody [GT289]

IL1 beta antibody [GT289]

GTX634188

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Product group Antibodies

ReactivityHuman

TargetIL1B

Overview

Supplier
GeneTex
Product Name
IL1 beta antibody [GT289]
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
GT289
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID3553
Target name
IL1B
Target description
interleukin 1 beta
Target synonyms
IL-1, IL1-BETA, IL1F2, IL1beta, interleukin-1 beta, IL-1 beta, catabolin, interleukin 1beta, preinterleukin 1 beta, pro-interleukin-1-beta
Host
Mouse
Isotype
IgG2a
Protein IDP01584
Protein Name
Interleukin-1 beta
Scientific Description
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq]
Reactivity
Human
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Stackowicz J, Gaudenzio N, Serhan N, et al. Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome. J Exp Med. 2021,218(10). doi: 10.1084/jem.20201466
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