IL10 Receptor alpha antibody [37607]

GeneTex

IL10 Receptor alpha antibody [37607]

9

The antibody has the ability to block cell surface human IL-10 Rα mediated bioactivity induced by recombinant human IL-10. The antibody does not cross-react with mouse IL-10 Rα.

Neutralizing/Inhibition: 0.03-0.1 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Neutralisation/Blocking

Research Use Only

Monoclonal

37607

Unconjugated

IL10RA

interleukin 10 receptor subunit alpha

CD210; CD210a; CDW210A; HIL-10R; IL-10 receptor subunit alpha; IL10R; IL-10R subunit 1; IL-10R subunit alpha; IL-10R1; IL-10RA; interleukin 10 receptor, alpha; interleukin-10 receptor alpha chain; interleukin-10 receptor subunit 1; interleukin-10 receptor subunit alpha

Mouse

IgG1

Interleukin-10 receptor subunit alpha

Interleukin 10, initially named cytokine synthesis inhibitory factor (CSIF), is a potent immunosuppressant of macrophage functions. IL10, a pleiotropic cytokine, exerts either immunostimulatory or immunosuppressive effects on a number of cell types, including Thy2 cells, activated fetal thymocytes, macrophages, keratinocytes, and LY-1 (CD5+) and normal B cells. IL10 stimulates the growth of stem cells, mast cells, and thymocytes and also enhances cytotoxic T cell development, costimulates B cell differentiation, and immunoglobulin secretion. Interleukin 10 binds specifically and with high affinity to cell-surface receptors. Interleukin 10 receptors are members of the class II subgroup of the cytokine receptor superfamily. Mouse and human cDNA clones encoding the ligand binding IL10 receptor have been isolated. The IL10 receptor complex contains two distinct type II cytokine receptor subunits, the ligand binding IL10RA and the IL10RB. The coexpression of both chains is essential for IL10 induced signal transduction. The beta chain serves as an accessory chain essential for the active IL10 receptor complex and necessary for the initiation of signal transdunction. Interleukin 10 receptors are expressed in all cell types that are known to respond to IL10. The human interleukin 10 receptor gene maps to chromosome 11q23.3.7

Human

-20°C or -80°C,2°C to 8°C

12352203