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IL2 Receptor alpha antibody [BC96]

Name: IL2 Receptor alpha antibody [BC96]
SKU: GTX01471_G10
Availability: BackOrder

GTX01471

ApplicationsFlow Cytometry

Product group Antibodies

ReactivityHuman, Monkey, Primate

TargetIL2RA

Overview

Supplier
GeneTex
Product Name
IL2 Receptor alpha antibody [BC96]
Delivery Days Customer
9
Application Supplier Note
*Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Flow Cytometry
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
BC96
Concentration
0.5 mg/ml
Conjugate
Unconjugated
Gene ID3559
Target name
IL2RA
Target description
interleukin 2 receptor subunit alpha
Target synonyms
CD25, IDDM10, IL2R, IMD41, TCGFR, p55, interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2R subunit alpha, TAC antigen, interleukin 2 receptor, alpha
Host
Mouse
Isotype
IgG1
Protein IDP01589
Protein Name
Interleukin-2 receptor subunit alpha
Scientific Description
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
Reactivity
Human, Monkey, Primate
Storage Instruction
2°C to 8°C
UNSPSC
12352203

Willer DO, Ambagala AP, Pilon R, et al. Experimental infection of Cynomolgus Macaques (Macaca fascicularis) with human varicella-zoster virus. J Virol. 2012,86(7):3626-34. doi: 10.1128/JVI.06264-11
Read this paper
Mori T, Miyamoto T, Yoshida H, et al. IL-1β and TNFα-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis. Int Immunol. 2011,23(11):701-12. doi: 10.1093/intimm/dxr077
Read this paper
Ruffell B, Au A, Rugo HS, et al. Leukocyte composition of human breast cancer. Proc Natl Acad Sci U S A. 2012,109(8):2796-801. doi: 10.1073/pnas.1104303108
Read this paper
Wan Q, Kozhaya L, ElHed A, et al. Cytokine signals through PI-3 kinase pathway modulate Th17 cytokine production by CCR6+ human memory T cells. J Exp Med. 2011,208(9):1875-87. doi: 10.1084/jem.20102516
Read this paper
Mackroth MS, Malhotra I, Mungai P, et al. Human cord blood CD4+CD25hi regulatory T cells suppress prenatally acquired T cell responses to Plasmodium falciparum antigens. J Immunol. 2011,186(5):2780-91. doi: 10.4049/jimmunol.1001188
Read this paper
Verhoeven D, Sankaran S, Silvey M, et al. Antiviral therapy during primary simian immunodeficiency virus infection fails to prevent acute loss of CD4+ T cells in gut mucosa but enhances their rapid restoration through central memory T cells. J Virol. 2008,82(8):4016-27. doi: 10.1128/JVI.02164-07
Read this paper