IL4 Receptor / CD124 antibody [4Y44]

GeneTex

IL4 Receptor / CD124 antibody [4Y44]

9

WB: 1:500 - 1:1000. IHC-P: 1:20 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking

Research Use Only

Monoclonal

4Y44

500 ug/ml

Unconjugated

IL4R

interleukin 4 receptor

CD124, IL-4RA, IL4RA, interleukin-4 receptor subunit alpha, IL-4 receptor subunit alpha, interleukin 13 receptor, interleukin-4 receptor alpha chain

Mouse

IgG2

Interleukin-4 receptor subunit alpha

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]

-20°C or -80°C,2°C to 8°C

12352203