ProductsBack/IL7 Receptor alpha antibody [A7R34] (Biotin)

FACS analysis of mouse C57Bl/6 splenocytes using GTX01473-02 IL7 Receptor alpha antibody [A7R34] (Biotin). Right panel : co-stained with IL7 Receptor alpha antibody [A7R34] (Biotin) and Mouse CD3 antibody (APC) Left panel : co-stained with isotype control and Mouse CD3 antibody (APC) antibody amount : 0.06 microg (5 microl)

IL7 Receptor alpha antibody [A7R34] (Biotin)

GTX01473-02

ApplicationsFlow Cytometry

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Product group Antibodies

TargetIl7r

Overview

Supplier
GeneTex
Product Name
IL7 Receptor alpha antibody [A7R34] (Biotin)
Delivery Days Customer
9
Application Supplier Note
*Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Flow Cytometry
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
A7R34
Concentration
0.5 mg/ml
Conjugate
Biotin
Gene ID16197
Target name
Il7r
Target description
interleukin 7 receptor
Target synonyms
CD127; IL-; IL-7 receptor alpha chain; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; IL-7Ralpha; IL-7R-alpha; interleukin 7 receptor alpha chain; interleukin-7 receptor subunit alpha
Host
Rat
Isotype
IgG2a
Protein IDP16872
Protein Name
Interleukin-7 receptor subunit alpha
Scientific Description
Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]
Storage Instruction
2°C to 8°C
UNSPSC
12352203

References

STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles. Alshekaili J et al., 2018 Feb 23, Sci Rep
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Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell. Thaventhiran JE et al., 2012 Aug 14, Proc Natl Acad Sci U S A
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In vivo administration of the recombinant IL-7/hepatocyte growth factor beta hybrid cytokine efficiently restores thymopoiesis and naive T cell generation in lethally irradiated mice after syngeneic bone marrow transplantation. Jin J et al., 2011 Feb 15, J Immunol
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LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen. Vondenhoff MF et al., 2009 May 1, J Immunol
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Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis. Leithaeuser F et al., 2006 Jun, Am J Pathol
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TCR signals mediated by Src family kinases are essential for the survival of naive T cells. Seddon B et al., 2002 Sep 15, J Immunol
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Expression and function of the interleukin 7 receptor in murine lymphocytes. Sudo T et al., 1993 Oct 1, Proc Natl Acad Sci U S A
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IL7 Receptor alpha antibody [A7R34] (Biotin)

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Overview

References

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