ProductsBack/IL7 Receptor alpha antibody [A7R34] (Biotin)

FACS analysis of mouse C57Bl/6 splenocytes using GTX01473-02 IL7 Receptor alpha antibody [A7R34] (Biotin). Right panel : co-stained with IL7 Receptor alpha antibody [A7R34] (Biotin) and Mouse CD3 antibody (APC) Left panel : co-stained with isotype control and Mouse CD3 antibody (APC) antibody amount : 0.06 microg (5 microl)

IL7 Receptor alpha antibody [A7R34] (Biotin)

GTX01473-02

ApplicationsFlow Cytometry

Product group Antibodies

TargetIl7r

Overview

Supplier
GeneTex
Product Name
IL7 Receptor alpha antibody [A7R34] (Biotin)
Delivery Days Customer
9
Application Supplier Note
*Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Flow Cytometry
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
A7R34
Concentration
0.5 mg/ml
Conjugate
Biotin
Gene ID16197
Target name
Il7r
Target description
interleukin 7 receptor
Target synonyms
CD127, IL-7Ralpha, interleukin-7 receptor subunit alpha, IL-7 receptor alpha chain, IL-7 receptor subunit alpha, IL-7R subunit alpha, IL-7R-alpha, IL-7RA, interleukin 7 receptor alpha chain
Host
Rat
Isotype
IgG2a
Protein IDP16872
Protein Name
Interleukin-7 receptor subunit alpha
Scientific Description
Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]
Storage Instruction
2°C to 8°C
UNSPSC
12352203

References

Alshekaili J, Chand R, Lee CE, et al. STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles. Sci Rep. 2018,8(1):3529. doi: 10.1038/s41598-018-21389-8
Read this paper
Thaventhiran JE, Hoffmann A, Magiera L, et al. Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell. Proc Natl Acad Sci U S A. 2012,109(33):E2223-9. doi: 10.1073/pnas.1209115109
Read this paper
Jin J, Goldschneider I, Lai L. In vivo administration of the recombinant IL-7/hepatocyte growth factor β hybrid cytokine efficiently restores thymopoiesis and naive T cell generation in lethally irradiated mice after syngeneic bone marrow transplantation. J Immunol. 2011,186(4):1915-22. doi: 10.4049/jimmunol.1001238
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Vondenhoff MF, Greuter M, Goverse G, et al. LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen. J Immunol. 2009,182(9):5439-45. doi: 10.4049/jimmunol.0801165
Read this paper
Leithäuser F, Meinhardt-Krajina T, Fink K, et al. Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis. Am J Pathol. 2006,168(6):1898-909.
Read this paper
Seddon B, Zamoyska R. TCR signals mediated by Src family kinases are essential for the survival of naive T cells. J Immunol. 2002,169(6):2997-3005.
Read this paper
Sudo T, Nishikawa S, Ohno N, et al. Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc Natl Acad Sci U S A. 1993,90(19):9125-9.
Read this paper

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IL7 Receptor alpha antibody [A7R34] (Biotin)

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Overview

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