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ProductsBack/IL7 Receptor alpha antibody [A7R34]

IL7 Receptor alpha antibody [A7R34]

Research Use Only
GTX01473
GeneTex
ApplicationsFlow Cytometry, ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Other Application
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
TargetIl7r
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Overview

  • Supplier
    GeneTex
  • Product Name
    IL7 Receptor alpha antibody [A7R34]
  • Delivery Days Customer
    9
  • Applications
    Flow Cytometry, ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Other Application
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    A7R34
  • Concentration
    0.5 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID16197
  • Target name
    Il7r
  • Target description
    interleukin 7 receptor
  • Target synonyms
    CD127; IL-; IL-7 receptor alpha chain; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; IL-7Ralpha; IL-7R-alpha; interleukin 7 receptor alpha chain; interleukin-7 receptor subunit alpha
  • Host
    Rat
  • Isotype
    IgG2a
  • Scientific Description
    Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles. Alshekaili J et al., 2018 Feb 23, Sci Rep
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  • Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell. Thaventhiran JE et al., 2012 Aug 14, Proc Natl Acad Sci U S A
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  • In vivo administration of the recombinant IL-7/hepatocyte growth factor beta hybrid cytokine efficiently restores thymopoiesis and naive T cell generation in lethally irradiated mice after syngeneic bone marrow transplantation. Jin J et al., 2011 Feb 15, J Immunol
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  • LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen. Vondenhoff MF et al., 2009 May 1, J Immunol
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  • Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis. Leithaeuser F et al., 2006 Jun, Am J Pathol
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  • TCR signals mediated by Src family kinases are essential for the survival of naive T cells. Seddon B et al., 2002 Sep 15, J Immunol
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  • Expression and function of the interleukin 7 receptor in murine lymphocytes. Sudo T et al., 1993 Oct 1, Proc Natl Acad Sci U S A
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