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IL7 Receptor alpha antibody [A7R34]

Name: IL7 Receptor alpha antibody [A7R34]
SKU: GTX01473_G10
Availability: BackOrder

GTX01473

ApplicationsFlow Cytometry, ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Other Application

Product group Antibodies

ReactivityHuman, Mouse

TargetIl7r

Overview

Supplier
GeneTex
Product Name
IL7 Receptor alpha antibody [A7R34]
Delivery Days Customer
9
Application Supplier Note
*Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Flow Cytometry, ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Other Application
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
A7R34
Concentration
0.5 mg/ml
Conjugate
Unconjugated
Gene ID16197
Target name
Il7r
Target description
interleukin 7 receptor
Target synonyms
CD127, IL-7Ralpha, interleukin-7 receptor subunit alpha, IL-7 receptor alpha chain, IL-7 receptor subunit alpha, IL-7R subunit alpha, IL-7R-alpha, IL-7RA, interleukin 7 receptor alpha chain
Host
Rat
Isotype
IgG2a
Protein IDP16872
Protein Name
Interleukin-7 receptor subunit alpha
Scientific Description
Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]
Reactivity
Human, Mouse
Storage Instruction
2°C to 8°C
UNSPSC
12352203

References

Su F, Li J, Xue Y, et al. Early Oral Administration of Ginseng Stem-Leaf Saponins Enhances the Peyer's Patch-Dependent Maternal IgA Antibody Response to a PEDV Inactivated Vaccine in Mice, with Gut Microbiota Involvement. Vaccines (Basel). 2023,11(4). doi: 10.3390/vaccines11040830
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Alshekaili J, Chand R, Lee CE, et al. STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles. Sci Rep. 2018,8(1):3529. doi: 10.1038/s41598-018-21389-8
Read this paper
Thaventhiran JE, Hoffmann A, Magiera L, et al. Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell. Proc Natl Acad Sci U S A. 2012,109(33):E2223-9. doi: 10.1073/pnas.1209115109
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Jin J, Goldschneider I, Lai L. In vivo administration of the recombinant IL-7/hepatocyte growth factor β hybrid cytokine efficiently restores thymopoiesis and naive T cell generation in lethally irradiated mice after syngeneic bone marrow transplantation. J Immunol. 2011,186(4):1915-22. doi: 10.4049/jimmunol.1001238
Read this paper
Vondenhoff MF, Greuter M, Goverse G, et al. LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen. J Immunol. 2009,182(9):5439-45. doi: 10.4049/jimmunol.0801165
Read this paper
Leithäuser F, Meinhardt-Krajina T, Fink K, et al. Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis. Am J Pathol. 2006,168(6):1898-909.
Read this paper
Seddon B, Zamoyska R. TCR signals mediated by Src family kinases are essential for the survival of naive T cells. J Immunol. 2002,169(6):2997-3005.
Read this paper
Sudo T, Nishikawa S, Ohno N, et al. Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc Natl Acad Sci U S A. 1993,90(19):9125-9.
Read this paper

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IL7 Receptor alpha antibody [A7R34]

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Overview

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