ILS-920

MedChem Express

ILS-920 [892494-07-4]

10

892494-07-4

Research Use Only

C57H86N2O14

1023.30

ILS-920 is a nonimmunosuppressive Rapamycin analog with reduced immunosuppressive activity and potent neuroprotective activity. ILS-920 binds selectively to the immunophilin FKBP52 and to the beta1-subunit of L-type voltage-gated calcium channels (VGCC) . ILS-920 shows 200-fold selectivity for FKBP52 versus FKBP12 [1] .

O[C@H]1[C@H](OC)C[C@H](C[C@@H](C)[C@@H](OC([C@@H]2CCCCN2C(C([C@@]3(O)[C@H](C)CC[C@@H](C[C@H](OC)/C(C)=C/[C@@H]4ON(C5=CC=CC=C5)[C@H]([C@H](C[C@H]6C)C)CC4)O3)=O)=O)=O)CC([C@H](C)/C=C(C)/[C@@H](O)[C@@H](OC)C6=O)=O)CC1

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